HOW TO DOSE AND ADMINISTER OTEZLA1

get-started-apr

The recommended adult dose (≥ 18 years of age and older) of OTEZLA is 30 mg BID. An initial titration schedule is required, as shown in the table below to reduce the risk of gastrointestinal symptoms.

Dose titration schedule

  Day 1 Day 2 Day 3 Day 4 Day 5 Day 6
AM 10 mg 10 mg 10 mg 20 mg 20 mg 30 mg
PM 10 mg 20 mg 20 mg 30 mg 30 mg

After an initial titration period, OTEZLA is administered
orally as one 30 mg tablet twice daily1*

otezla-30mg-tablet

5-day titration schedule provided via starter pack

  • Can be administered with or without food
  • Tablets should not be split, crushed, or chewed
  • OTEZLA dosage should be reduced to 30 mg once daily in patients with severe renal impairment†
    • – For initial dosage titration in patients with severe renal impairment, it is recommended that OTEZLA be titrated using only the AM schedule and the PM doses be skipped. From day 6 on, the dose of OTEZLA is 30 mg once daily.

OTEZLA offers the simplicity of oral dosing.

* An initial titration schedule is required to reduce the risk of gastrointestinal symptoms. Please see the Product Monograph for titration schedule.

† Severe renal impairment defined as creatinine clearance (CrCl) of less than 30 mL per minute estimated by the Cockroft–Gault equation.

BID, twice daily.